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In this study, we demonstrate that VDR is essential for the morphogenetic process that drives hair cycle development and cell division in the hair follicle (HF). We have identified Vdr as a key regulator of catagen, by demonstrating that Vdr cKO may result from impaired apoptosis in the epithelial strands of the HF cell during the catagen phase. The delay in the entry of the HF to anagen can cause alopecia. the HF turns into a dermal cyst composed of epidermal cell.
To examine the role played by VDR in the regulation of apoptosis in catagen, we conducted an extensive search for possible VDR targets using functional annotation enrichment analysis. Comparing the control CO fibroblasts with those VDR non-liganded CO fibroblasts, we observed that 268 genes were upregulated and 1,25D-dependent activation is downregulated. The majority of these genes are increased by fibroblasts of WT.
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